On August 4th, 1900, a ballast train working on the TH&B line south of West Brantford was hit by an express passenger train. The engineer of the express, James Gilmore, was killed and many others were injured.
On the 18th of January, 1929, Michigan Central #8428 pulling train number 83 was involved in a serious accident along the Niagara Escarpment above Stony Creek. The roadbed under the track washed out just before the train arrived. The fireman, Mark Ricker, was killed and the engineer, Patrick Gant was seriously injured.
On the 4th of March, 1942, there was a fire at the Aberdeen Car shops. Among the damages, baggage car number 55 and second-class coach number 70 were destroyed.
TH&B engine #49 collided with a truck at Beach Rd. in Hamilton on the 28th of April, 1944. The engineer was killed, and the locomotive and five cars derailed.
The first GP7 unit built at EMD's London facility was TH&B number 71. There had been some discussion about preserving her for posterity, but nothing was done (the discussions seem to have been largely outside the company...). On February 12, 1980, unit 71 was hit broadside at the Webber Road grade crossing just west of Welland. The driver of the tractor-trailer was killed, but the engine crew managed to escape serious injury. Number 71 was damaged beyond repair. The only part salvaged was the locomotive's bell, which was given to the President of CP Rail (R.J. Ritchie).